Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic
Identifieur interne : 000D31 ( Main/Exploration ); précédent : 000D30; suivant : 000D32Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: Lessons from the 2009 pandemic
Auteurs : Hans D. Klenk [Allemagne] ; Wolfgang Garten [Allemagne] ; Mikhail Matrosovich [Allemagne]Source :
- BioEssays [ 0265-9247 ] ; 2011-03.
Descripteurs français
- KwdFr :
- Animaux, Grippe chez les oiseaux (transmission), Grippe chez les oiseaux (épidémiologie), Grippe humaine (transmission), Grippe humaine (épidémiologie), Humains, Oiseaux, Pandémies, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (pathogénicité), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (pathogénicité), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (pathogénicité), Spécificité d'hôte, Virus recombinants (génétique), Virus recombinants (pathogénicité).
- MESH :
- génétique : Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus recombinants.
- pathogénicité : Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Virus recombinants.
- épidémiologie : Grippe chez les oiseaux, Grippe humaine.
- Animaux, Humains, Oiseaux, Pandémies, Spécificité d'hôte.
English descriptors
- KwdEn :
- Animals, Birds, Host Specificity, Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (pathogenicity), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (pathogenicity), Influenza in Birds (epidemiology), Influenza in Birds (transmission), Influenza, Human (epidemiology), Influenza, Human (transmission), Pandemics, Reassortant Viruses (genetics), Reassortant Viruses (pathogenicity).
- MESH :
- epidemiology : Influenza in Birds, Influenza, Human.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- pathogenicity : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- transmission : Influenza in Birds, Influenza, Human.
- Teeft :
- Acad, Airway, Animal viruses, Animals, Antigenic, Aquatic birds, Avian, Avian virus, Avian viruses, Bioessays, Birds, Classical swine virus, Cleavage, Cleavage activation, Cleavage site, Determinant, Distress syndrome, Epithelium, Furin, Garten, Gene, Gene reassortment, Haemagglutinin, Hemagglutinin, Hong kong, Host Specificity, Host factors, Host range, Hpai, Hpai viruses, Human airway epithelium, Human infection, Human population, Human viruses, Humans, Interspecies transmission, Kawaoka, Klenk, Lpai, Lpai viruses, Mammalian cells, Matrosovich, Molecular basis, Mutation, Natl, Next pandemic, Outbreak, Overview, Pandemic, Pandemic virus, Pandemics, Pathogenic, Pathogenicity, Polymerase, Polymerase activity, Proc, Proc natl acad, Prospects overviews, Protease, Reassortment, Receptor, Replication, Respiratory tract, Review essays, Severe cases, Southern china, Subtype, Subtypes, Surface glycoproteins, Viral, Viral polymerase, Viral proteins, Virol, Virology, Virus, Virus hemagglutinin, Virus polymerase, Virus replication, Wild birds, Wiley periodicals.
Abstract
The emergence of the 2009 H1N1 virus pandemic was unexpected, since it had been predicted that the next pandemic would be caused by subtype H5N1. We also had to learn that a pandemic does not necessarily require the introduction of a new virus subtype into the human population, but that it may result from antigenic shift within the same subtype. The new variant was derived from human and animal viruses by genetic reassortment in the pig, supporting the concept that this animal is the mixing vessel for the generation of new human influenza viruses. Although it is generally believed that the 2009 outbreak was mild, there have been severe cases particularly among the young and the middle‐aged. Pathogenicity and host range are determined to a large extent by the polymerase, the haemagglutinin and the NS1 protein of influenza A viruses. There is evidence that mutations of these proteins may change the pathogenicity of the new virus.
The unexpected emergence of the 2009 H1N1 pandemic showed that an influenza pandemic does not necessarily require the introduction of a new virus subtype into the human population but may also result from antigenic shift within the same subtype.
Url:
DOI: 10.1002/bies.201000118
Affiliations:
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Le document en format XML
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<term>Grippe humaine (épidémiologie)</term>
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<term>Animal viruses</term>
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<front><div type="abstract" xml:lang="en">The emergence of the 2009 H1N1 virus pandemic was unexpected, since it had been predicted that the next pandemic would be caused by subtype H5N1. We also had to learn that a pandemic does not necessarily require the introduction of a new virus subtype into the human population, but that it may result from antigenic shift within the same subtype. The new variant was derived from human and animal viruses by genetic reassortment in the pig, supporting the concept that this animal is the mixing vessel for the generation of new human influenza viruses. Although it is generally believed that the 2009 outbreak was mild, there have been severe cases particularly among the young and the middle‐aged. Pathogenicity and host range are determined to a large extent by the polymerase, the haemagglutinin and the NS1 protein of influenza A viruses. There is evidence that mutations of these proteins may change the pathogenicity of the new virus.</div>
<div type="abstract" xml:lang="en">The unexpected emergence of the 2009 H1N1 pandemic showed that an influenza pandemic does not necessarily require the introduction of a new virus subtype into the human population but may also result from antigenic shift within the same subtype.</div>
</front>
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<name sortKey="Garten, Wolfgang" sort="Garten, Wolfgang" uniqKey="Garten W" first="Wolfgang" last="Garten">Wolfgang Garten</name>
<name sortKey="Klenk, Hans D" sort="Klenk, Hans D" uniqKey="Klenk H" first="Hans D." last="Klenk">Hans D. Klenk</name>
<name sortKey="Klenk, Hans D" sort="Klenk, Hans D" uniqKey="Klenk H" first="Hans D." last="Klenk">Hans D. Klenk</name>
<name sortKey="Matrosovich, Mikhail" sort="Matrosovich, Mikhail" uniqKey="Matrosovich M" first="Mikhail" last="Matrosovich">Mikhail Matrosovich</name>
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